Zinc-mediated Carboxylations of Allylic and Propargylic Halides in Flow: Synthesis of β-Lactones via Subsequent Bromolactonization
Congrats to Patrick, Guowei and Sreekumar for the first Romo group publication of the year! Zinc-mediated carboxylations in flow; out now in RSC Advances!
Total Synthesis of (±)-N-Methyldibromoisophakellin and N-Methylugibohlin via Net [3+2] Cycloguanidinylations Employing 2-Amido-1,3-Diamino-Allyl Cations
A collaborative effort between the Romo/Wood labs is now published in the Special Issue honoring Prof. Wood in Tetrahedron Letters. Congrats Nobuyuki and Tae!
Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy
We are excited to report the total synthesis of rameswarelide via a pharmacophore-directed retrosynthetic strategy! Congrats to Nate on his publication, out now in JACS ASAP!
Synthesis and Stability Studies of a Simplified, Thiazole-Containing Macrocycle of the Anticancer Agent Salarin C
Congratulations to Evan and Roxane on their recently published article in Organic Letters!
Congratulations to Nate Truax for succefully defending his dissertation! Good luck in the Baran lab!
Congrats to Sreekumar on his recent publication on salinosporamide, out now in Nat. Chem. Biol.!
Congratulations to Sigrid, Patrick and Evan for receiving the Baylor Graduate School travel award to present their research at FlotHet and ACS this spring!
Multi-component, Enantioselective Synthesis of Tetrahydropyridazinones Employing Chiral, a,b-Unsaturated Acylammonium Salts
Congratulations to Sigrid, Roxane and Sreekumar on their work towards the enantioselective synthesis of tetrahydropyridazinones, accepted to Org. Lett.!
Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(S,E)-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate
Congratulations to Conner and Dr. Chaheine on their organic synthesis procedure employing the NCMPL, accepted to Org. Syn.!
Synthesis of Agelastatin A and Derivatives Premised on a Hidden Symmetry Element Leading to Analogs Displaying Anticancer Activity
Congratulations to Haoran on his synthesis of Agelastatin A and derivatives, published in Tetrahedron!
Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A
Congratulations to Keighley (Taube group) and Tao on their publication exploring the anticancer activity of ophiobolin A, published in Scientific Reports!
Enantioselective, Organocatalytic Strategy for the Oxazolomycin Core: Formal Synthesis of (+)-Neooxazolomycin
More congratulations to Christian on his publication of his PhD work on the oxazolomycins in Organic Letters!
Mad props to Christian for defending his PhD Thesis, focusing on his work towards the total synthesis of oxazolomycin B and his completed formal synthesis of neooxazolomycin. Yay Dr. Chaheine!
Congratulations to Sigrid for her collaborative review on waixenicin A, published in Acta Pharmacologica Sinica!
Big congrats to Nate for his review being accepted to Natural Product Reports on the different approaches to total synthesis and drug discovery! Make sure to read his description of our concept of Pharmacophore-Directed Retrosynthesis and how we have applied it to natural prodcuts.
Congratulations to Guowei on successfully defending his dissertation and best of wishes with his new postdoc position in the Yu lab at SCRIPPS!
Congratulations to Tao on successfully defending his dissertation and best of wishes with his new postdoc position in the Cravatt lab at SCRIPPS!
Generation and Reactivity of 2-Amido-1,3-diaminoallyl Cations: Cyclic Guanidine Annulations via Net (3 + 2) and (4 + 3) Cycloadditions
Congratulations to Ragha and Haoran on their recent publication on Guanidine Annulations via Net (3 + 2) and (4 + 3) Cycloadditions, published in Organic Letters!
New group members
Welcome to our new graduate student, Conner Song!
Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Sinularia Natural Product Tricyclic Cores
Congratulations to Nate for his recent publication on pharmacophore-directed retrosynthetic studies of Rameswaralide, published in Organic Letters!
Gracilin A Derivatives Target Early Events in Alzheimer’s Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress.August, 2019
Go team Gracillin! Congratulations to Christian, Mike and our wonderful collaborators in the Botana group for their work with the Gracillin A derivatives, recently published in ACS Chemical Neuroscience!
Congratulations to Tao for his work on the synthesis of Hypercalin C in collaboration with the Taube lab at Baylor, published in Angewandte Chemie!
A Novel Actin Binding Drug with In Vivo EfficacyJanuary, 2019
Congratulations to the TAMU LINCHPIN lab and collaborators for the discovery of a new actin binding drug published in Antimicrobial Agents and Chemotherapy!
New group membersJanuary, 2019
Welcome to our two new graduate students, Evan Woods and Patrick Sutter!
(−)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic StudyJuly, 2018
Props to Sreekumar and Henry for their Marine Drugs paper on the biological mode of action of (-)-Homosalinosporamide!
Enantioselective Synthesis of Medium-Sized Lactams via Chiral α,ß-Unsaturated Acylammonium SaltsApril, 2018
Congratulations to Guowei, Masaki and Sreekumar on their Angewante Chemie paper describing the synthesis of medium sized rings using our acylammonium methodology!
Welcome to Sigrid, Jamie and Nate!December, 2017
A warm welcome to our new first year graduate students, Nathanyal Truax, Jamie Suzuki and Sigrid Kiledal!
Multicomponent, Enantioselective Michael-Michael-Aldol-β-Lactonizations Delivering Complex β-LactonesDecember, 2017
Congratulations to Khoi for his paper on the multicomponent acylammonium-catalyzed Michael-Michael-Aldol-Lactonization reaction in J. Org. Chem!
Quantitative Chemoproteomic Profiling Reveals Multiple Target Interactions of Spongiolactone Derivatives in Leukemia CellsNovember, 2017
Big shout out to Tao as well as previous members Natalie and Ta for their collaborative work with Prof. Stefan Sieber in Chem. Comm. on derivatives of spongiolactone!
Diastereo- and Enantioselective Synthesis of Bi- and Tricyclic N-Heterocycle-Fused β-LactonesNovember, 2017
Kudos to Weixu for his paper in J. Org. Chem. on the synthesis of N-heterocycle fused β-Lactones!
Dr. Michael ConnerOctober, 2017
Welcome to our new postdoc Dr. Michael Conner! Mike obtained his PhD from Indiana University under Dr. Kevin Brown.
Congratulations to Morgan and JC for their collaborative work with Prof. Jun Liu in Cell Chem. Bio. on the discovery of the cellular target of Agelastatin A!
Congrats to Mikail and Weixu for their paper accepted in Org. Biomol. Chem. describing enantioselective Diels-Alder-Lactamization organocascades employing a furan-based diene.
A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat HybridsJanuary, 2017
Congrats to Mingzhao, Omar, Ken and the TAMU MiniPharma for their paper accepted in Bioorg. Med. Chem. Lett. on a strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-Orlistat hybrids.
Telescoped Synthesis of γ-Bromo-β-Lactones from Allylic Bromides Employing Carbon DioxideJanuary, 2017
Congrats to Sreekumar for his publication in Isr. J. Chem. on the telescoped synthesis of γ-bromo-β-lactones from allylic bromides employing carbon dioxide.
Dr. Venkata KovvuriJuly, 2016
Welcome to our new postdoc Dr. Venkata Kovvuri (Ph.D., with Dr. J. S. Yadav, Indian Institute of Chemical Technology)
Much kudos to Khoi for his significant achievement in writing a book chapter that's now published!
Congrats to Mikail for his paper on Diels‐Alder‐Initiated Organocascades Employing α,β-Unsaturated Acylammonium Salts has just been accepted by Chemical Science.
Review on Acylammonium SaltsJuly, 2016
Congrats to Sreekumar for his review article on ACIE about the utility of unsaturated acylammonium salts in organocatalysis.
Visiting Scholar Masaki YamagamiJuly, 2016
Welcome to Masaki Yamagami, visiting scholar from Osaka University (From Prof. Michio Murata)!
Assistant Professor Dr. Paul GladenMay, 2016
Congratulations to Dr. Paul Gladen on his new assistant professorship at Lake Forest College in Chicago!
Derivatization of Agelastatin A Leading to Bioactive Analogs and a Trifunctional Probe15 April, 2016
Kudos to previous members Dr. Morgan Jouanneau and Dr. JC Reyes on their publication in Bioorganic & Medicinal Chemistry Letters on derivatives and bioactive analogs of Agelastatin A!
Postdoc Dr. Morgan JouanneauJanuary, 2016
Congratulations to Dr. Morgan Jouanneau on his postdoc in Dr. Janine Cossy's group!
Postdoc Dr. Mikail AbbasovJanuary, 2016
Kudos to Dr. Mikail Abbasov for successfully defending his dissertation and his new postdoc position in the Cravatt lab at SCRIPPS!
Visiting Scholar Ariane Fernandes BertonhaNovember, 2015
Welcome to Ariane Fernandes Bertonha, visiting scholar from São Paulo University (from Prof. R. Berlinck’s Group)!
HP Ink Chemist Dr. Natalie HarveySeptember, 2015
Congratulations to Dr. Natalie Harvey for successfully defending her dissertation and her new position as an Ink Chemist at HP!
Utility and NMR studies of Acylammonium Salts10 March, 2015
Kudos to Sreekumar and Khoi for their recently published Tetrahedron Lett. article describing the utility and NMR studies of acylammonium salts!
Synthesis of (±)-Spongiolactone8 December, 2014
Kudos to Natalie for her recently published Chem. Eur. J. article describing the total synthesis of (±)-Spongiolactone!
2-Bromo-N-Propyl Pyridinium Triflate20 October, 2014
Congrats to Morgan for his contribution to Encyl. Reag. Org. Syn. describing the modified Mukaiyama's reagent!
Dr. Paul Gladen (Ph.D. w/ David Williams, Indiana University)4 September, 2014
Welcome to our new post-doc Dr. Paul Gladen (Ph.D. w/ David Williams, Indiana University).
Congrats to Mikail for his recently published highlight in Nat. Prod. Rep. on asymmetric covalent organocatalysis in scalable natural product synthesis.
Congrats to Mikail for receiving the Richard W. Schmude, Jr. Endowed Graduate Scholarship in Chemistry.
Spring 2014 National ACS Meeting in Dallas, TX16–20 March, 2014
Congrats to Sreekumar, Mikail, Natalie, and Khoi on their successful presentations at the National ACS Meeting in Dallas!
Kudos to Mikail for his recently accepted J. Am. Chem. Soc. communication describing a new and versatile class of chiral dienophiles! Article was featured in JACS Spotlights, Synfacts and Advances in Engineering!
Research Chemist Dr. Morgan Shirley (Chevron, Richmond/San Francisco)12 February, 2014
Congrats to Dr. Morgan Shirley for successfully defending her dissertation and starting her positions as a Research Chemist at Chevron.
Chemo- and Site-Selective Derivatizations of Natural Products27 January, 2014
Congrats to Omar for his recently published review in Nat. Prod. Rep. on the chemo- and site-selective derivatizations of natural products.
Welcome to our new post-doc Dr. Morgan Jouanneau (Ph.D. w/ Jean-Pierre Férézou, Université Paris-Sud 11).
Congrats to Mikail for receiving the George Bush Presidential Library Foundation Grant and Martell Travel Award.
Direct Catalytic Asymmetric Synthesis of N-Heterocycles from Commodity Acid Chlorides31 October, 2013
Kudos to Sreekumar and Khoi for their recently published Angew. Chem. article describing an organocatalytic asymmetric synthesis of N-heterocycles! Article was highlighted in Synfacts (heterocycles) and Synfacts (organocatalysis)!
Rapid Assembly of Complex Cyclopentanes Employing Chiral, Acylammonium Intermediates26 September, 2013
Congrats to Gang, Morgan, Khoi and Rae Lynn for their recently published Nature Chem. article describing a rapid assembly of complex cyclopentanes! Article was highlighted in C&EN, BioNewTexas, and Synform!
Dr. Nathan Collett (Ph.D. w/ Rich Carter, Oregon State University)2 September, 2013
Welcome to our new post-doc Dr. Nathan Collett (Ph.D. w/ Rich Carter, Oregon State University).
Congrats to Dr. JC Reyes for successfully defending his dissertation and starting his positions as a Research Chemist at Dow Chemical Co.
Congrats to Beatrice and Omar for their short synthesis of Homobenzotetramisole and congeners in J. Org. Chem.!
Simultaneous Structure–Activity Studies and Arming of Natural Products by C–H Amination19 May, 2013
Congrats to Jing, Cong-Ying and our collaborators in the Cravatt and Rodriguez laboratories for our joint paper in Nature Chemistry.
University Awards and Fellowships20 March, 2013
Congrats to Morgan Shirley for receiving the Montgomery Graduate Endowed Fellowship, Buck Weirus Aggie Spirit Award, and Guseman Award.
Dow Chemical Graduate Fellowship17 February, 2013
Congrats to JC Reyes for receiving the Dow Chemical Graduate Fellowship and Sharon Dabney Memorial Scholarship.
Dr. Fred Briones (Ph.D. w/ Huw Davies, Emory University)14 October, 2012
Welcome to our new post-doc Dr. Fred Briones (Ph.D. w/ Huw Davies, Emory University).
Congrats to Dr. Gang Liu for successfully defending his dissertation and starting his positions as a Medicinal Chemist at MD Anderson, Institute for Applied Cancer Sciences.
Bioinspired Total Synthesis of Agelastatin A11 June, 2012
Congrats to JC for his bioinspired synthesis of Agelastatin A that appeared in Angewandte Chemie! Article was featured on back cover, graphic contributed by JC!
Dr. Carolyn Leverett secured a Research Scientist position at Pfizer (Groton, CT)! Congrats Carolyn!
Former graduate student, Asst. Prof. Andy Mitchell (Illinois State University) received his first independent grant from Research Corporation! Way to go Andy!
Congrats to Wang for his contribution to the synthesis of 15N-labelled oroidin published in JNP in collaborative biosynthetic studies with the Molinski group.
Pyrrole-Aminoimidazole Alkaloid Metabiosynthesis with Marine Sponges14 February, 2012
Congrats to Wang for his collaborative biosynthetic studies with the Molinski group (UC San Diego) to appear in Angewandte Chemie!
Cyclopropanations of Natural Products for Simultaneous Arming and Structure Activity Studies13 February, 2012
Omar’s contribution to our toolbox for natural product simultaneous arming via cyclopropanations will appear in Org. Lett. Congrats!
Best wishes to Ta (Supakarn) as she starts a new chapter as an Asst. Professor in the Dept. of Pharmaceutical Sciences, Chulalongkorn University, Thailand having completed her Ph.D. in Fall 2011!
LKT Laboratories, Inc. - Specialty Biochemical Resource2 February, 2012
Congrats to Henry Nguyen who recently secured a Senior Scientist position at LKT Laboratories, Inc. in Minnesota!
ACS Division of Organic Chemistry Research Symposium30, January 2012
Congrats to JC for being the Departmental nominee for the ACS Division of Org. Chem. Research Symposium!
A Diastereoselective, Nucleophile-Promoted Aldol-Lactonization of Ketoacids Leading to Bicyclic-β-Lactones19 January, 2012
Kudos to Gang and Morgan for their recently accepted JOC Note describing a new and improved NCAL procedure!
Mechanistic Investigations of the ZnCl2-Mediated Tandem Mukaiyama Aldol Lactonization30 December, 2011
A full paper describing the full, rich, and long saga of the TMAL mechanism appeared in J. Am. Chem. Soc. Congrats to Zhao, Andy, and Ravi and thanks to Lisa (Lab for Molecular Simulation) for computational efforts!
Diazo Reagents for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural Products via OH Insertion26 August, 2011
Congrats to Ta (Supakarn) for her paper in ACS Chem. Biol. describing a strategy for natural product tagging in collaboration with the Liu Group at Johns Hopkins! Article was featured on cover, graphic contributed by Mikail!
Congrats to Carolyn for her mechanistic paper in JOC in collaboration with the Tantillo group at UC Davis!
Total Synthesis of (+)-Omphadiol14 July, 2011
Congrats to Gang for his elegant synthesis of Omphadiol that appeared in Angewandte Chemie! Article was featured on cover, graphic contributed by Mikail! Also highlighted on B.R.S.M. and TotallySynthetic blogs and in Synfacts!
Biosynthesis, Asymmetric Synthesis, and Pharmacology of Pyrrole-2-Aminoimidazole Marine Alkaloids3 July, 2011
Congrats to Manuel for his major contributions to the review in Natural Product Reports on the Pyrrole Aminoimidazole Alkaloids. Review was featured on cover, graphic contributed by Mikail!
Organocatalytic Enantioselective Synthesis of Bicyclic ß-Lactones from Aldehyde Acids via NCAL28 March, 2011
Our first Organic Synthesis procedure was published! Congrats to Henry, Seongho, Huda, and Diana!
Romo earns 2011 Distinguished Achievement Award for Research24 March, 2011
The 2011 Distinguished Achievement Awards will be formally presented at 1:30 p.m. April 27 during a ceremony in Rudder Theater. In recognition of their achievements, each recipient will receive a $4,000 cash gift, an engraved watch and a commemorative plaque.
Congrats to Henry, Gil, and Genzyme collaborators on the Salinosporamide A full story in JOC as a featured article! Also featured as January JOC issue cover art! Contribution by Ranjith C. Perumalil (Visual Arts Dept., TAMU) and our own Mikail!
Asymmetric NCAL with Ketoacids4 November, 2010
Congrats to Carolyn and Vikram on their ACIE paper describing a practical, asymmetric NCAL with Ketoacids.
Bioinspired Total Synthesis of (-)-Salinosporamide A and Derivatives3 November, 2010
Congrats to Henry, Gil, and Genzyme collaborators on the Salinosporamide A - full story in JOC as a featured article.
A. E. Martell Travel Awards1 November, 2010
Congrats to Ta, Morgan, and Gang on receiving the A. E. Martell Travel Award for the Spring ACS National Meeting.
Double Diastereoselective NCAL12 August, 2010
Congrats to Kay and Kevin on their OL paper describing Double Diastereoselective NCAL reactions and Oxygen Heterocycle-Fused Beta-Lactones.
Mild Arming and Derivatization of Natural Products13 April, 2010
Another mild natural product derivatization strategy was published in OL. Congrats to Cong-Ying, Jing, and Mahesh.
Synthesis of 15N-Oroidin and Biosynthetic Studies by Microscale 1H−15N HSQC and FTMS22 January, 2010
Congrats to Wang and JC for their synthesis of 15N-labelled oroidin published in JNP in collaborative biosynthetic studies with the Molinski group.
Inhibition of Nonsense-Mediated mRNA Decay by Pateamine A28 August, 2009
A new twist in the Pateamine A story was described in JBC. Congrats to the Liu-Romo team.